L.I. Medved’s Research Center of Preventive Toxicology, Food and Chemical Safety, Ministry of Health, Ukraine (State Enterprise), Kyiv, Ukraine

Abstract. Extremely high volumes of drugs production and consumption have become a global problem of modern times, which determines negative impact on human health and the living environment.
Aim: generalization of international best practices in monitoring the impact of production and consumption of synthetic drugs on the environment.
Materials and Methods. the reports by the European Monitoring Centre for Drug and Narcotics Control, the National Police of Ukraine and the Security Service of Ukraine, UN, WHO, materials from scientific libraries PUBMED, Elsevier were studied.
Results. According to the results of the latest monitoring in Ukraine, the dynamics of illegal drugs and psychoactive substances use per 10,000 population remains negative: from 14.7 in 2017 to 17.0 in 2022. However, under the conditions of martial law
and due to active hostilities in some regions of Ukraine, as well as because of limited access to relevant resources in these territories, individual monitoring subjects do not have the opportunity to exercise their powers in full. Therefore, obtaining comprehensive information on the volume of production and use of illegal drugs is not considered possible today. At the same time, according to the National Police of Ukraine, 94 drug laboratories were closed down in 2021 alone; four international channels of entry of illegal drugs into Ukraine were exposed; tons of drug materials and psychotropic substances were seized from illegal circulation as a result of completed investigations in criminal proceedings. The experience of EU countries proves that monitoring the concentration of synthetic drugs in environmental objects allows solving the following issues: assessing the nature and scale of drug use over time; identifying basic trends in drug consumption; determination of measures to control and mitigate the consequences of the production and consumption of synthetic drugs, which will effectively protect the environment from dangerous biologically active substances.
Conclusions. Although little is known about the actual extent of damage to the environment of illegal synthetic drugs, monitoring their presence in environmental objects is a relevant area of scientific research and should be a separate issue of public
health policy.
Keywords: drugs, environment.

СПИСОК ВИКОРИСТАНИХ ДЖЕРЕЛ / REFERENCES

1. China policies to promote local production of pharmaceutical products and protect public health. Geneva: World Health Organization; 2017. License: CC BY-NCSA 3.0 IGO. Cataloguing-in-Publication (CIP) data. URL: http://apps.who.int/iris.

2. World Drug Report 2023. Booklet 5. Drugs and the environment. URL: https://www.unodc.org/unodc/en/data-andanalysis/world-drug-report-2023.html.

3. Looking back on 25 years of annual reporting on the drugs problem in Europe. European Monitoring Centre for Drugs and Drug Addiction, 2020. URL: https://www.emcdda.europa.eu/publications/brochures/25-years-annual-reporting_en. doi:10.2810/199193.

4. European Drug Report 2020: Trends and Developments. European Monitoring Centre for Drugs and Drug Addiction (2020), Publications Office of the European Union, Luxembourg. URL: https://www.emcdda.europa.eu/publications/edr/trends-developments/2020_en. doi:10.2810/420678.

5. European Monitoring Center for Drugs and Drug Addiction (EMCDDA). European Drug Report 2021: Trends and Developments. Electronic resource. URL: https://www.emcdda.europa.eu/publications/edr/trends-developments/2021_en.

6. European Monitoring Centre for Drugs and Drug Addiction (2022), European Drug Report 2022: Trends and Developments, Publications Office of the European Union, Luxembourg. DOI: 10.2810/75644.

7. EMCDDA. National Report on Drug and Alcohol Situation in Ukraine, 2023 (based on data 2022). URL: https://www.emcdda.europa.eu/drugs-library/nationalreport-drug-and-alcohol-situation-ukraine-2023-baseddata-2022_en.

8. EMCDDA and Europol, Methamphetamine in Europe: EMCDDA Europol Threat Assessment 2019. (Luxembourg: Publications Office, 2019). URL: https://www.emcdda.europa.eu/publications/joint-publications/methamphetamine-threat-assessment_en.

9. World Drug Report 2020 (United Nations publication, Sales No. E.20.XI.6). URL: https://www.narkotik.pol.tr/kurumlar/narkotik.pol.tr/TUBİM/Uluslar-Arasi-Yayinlar/WORLD-DRUG-REPORT-2020-EXECUTIVE-SUMMARY.pdf

10. Lisa N Kates, Charles W Knapp, Helen E Keenan. Acute and chronic environmental effects of clandestine methamphetamine waste. The Science of the Total Environment. July 2014. 493C:781-788. DOI: 10.1016/j.scitotenv.2014.06.066.

11. Schoenmakers Yvette, Mehlbaum SL. Drugsafval in Brabant. Justitiële verkenningen. May 2017. 43(2):89- 102. DOI: 10.5553/JV/016758502017043002006.

12. Doyun Shin, Youngyeon Kim, Hee Sun Moon. Fate and toxicity of spilled chemicals in groundwater and soil environment I: strong acids. Environ Health Toxicol. 2018 Dec; 33(4): e2018019. Published online 2018 Dec 13. DOI: 10.5620/eht.e2018019.

13. Helena I Gomes, William M Mayes, Ian T. Burke, Andy Bray, Pauline Deutz. Resource Recovery and Remediation of Alkaline Wastes: CL: AIRE Bulletin. September 2019. DOI: 10.13140/RG.2.2.18476.41609.

14. Melnikova Natalia, Lizak Welles Wanda, Wilburn Rebecca E., Rice Nancy, Wu Jennifer, Stanbury Martha. Hazards of Illicit Methamphetamine Production and Efforts at Reduction: Data from the Hazardous Substances Emergency Events Surveillance System. Public Health Rep. 2011; 126(Suppl 1): 116–123. DOI: 10.1177/00333549111260S115.

15. Mafalda Pardal, Charlotte Colman, Tim Surmont. Synthetic Drug Production in Belgium – Environmental Harms as Collateral Damage? Journal of Illicit Economies and Development. October 2021. 3(1):36-49. DOI: 10.31389/jied.84.

16. Scott TL, Janusz A, Perkins MV, Megharaj M, Naidu R, Kirkbride KP. Effect of amphetamine precursors and by-products on soil enzymes of two urban soils. Bull Environ Contam Toxicol. 2003 Apr;70(4):824-31. DOI: 10.1007/s00128-003-0056-7.

17. Davey CJE, Kraak MHS, Praetorius A, ter Laak TL and van Wezel AP. Occurrence, hazard, and risk of psychopharmaceuticals and illicit drugs in European surface waters. Water Research. 2022. 222:118878, DOI: 10.1016/j.watres.2022.118878.

18. Kates Lisa N, Gauchotte-Lindsay Caroline, Daéid N. Nic, Keenan HE. Prediction of the Environmental Fate of Methylamphetamine Waste. Chapter In book: Environmental Forensics. January 2012. DOI: 10.1039/9781849734967-00262.

19. Hejna Monika, Kapuścińska Dominika, Aksmann Anna. Pharmaceuticals in the Aquatic Environment: A Review on Eco-Toxicology and the Remediation Potential of Algae. Int J Environ Res Public Health. 2022 Jul; 19(13): 7717. DOI: 10.3390/ijerph19137717.

20. Larsson DG Joakim. Pollution from drug manufacturing: review and perspectives. Philos Trans R Soc Lond B Biol Sci. 2014 Nov 19; 369(1656): 20130571. DOI: 10.1098/rstb.2013.0571.

21. Emke Erik, Evans Sian, Kasprzyk-Hordern Barbara, Pim de Voogt. Enantiomer profiling of high loads of amphetamine and MDMA in communal sewage: a Dutch perspective. Sci Total Environ. 2014 Jul 15:487:666-72. DOI: 10.1016/j.scitotenv.2013.11.043.

22. Reymond Naomi, Emke Erik, Boucheron Thea, Laak Thomas ter, Voogt Pim de, Esseiva Pierre, Been Frederic. Retrospective suspect and non-target screening combined with similarity measures to prioritize MDMA and amphetamine synthesis markers in wastewater. Science of The Total Environment. Volume 811, 10 March 2022, 152139. DOI: 10.1016/j.scitotenv.2021.152139.

23. Maasz Gabor, Molnar Eva, Mayer Matyas, Kuzma Monika, Takács Péter, Zrinyi Zita, Pirger Zsolt, Kiss Tibor. Illicit Drugs as a Potential Risk to the Aquatic Environment of a Large Freshwater Lake after a Major Music Festival. Environ Toxicol Chem. 2021 May;40(5):1491-1498. DOI: 10.1002/etc.4998.

24. Yadav Meena K, Short Michael D, Gerber Cobus, Awad John, van den Akker Ben, Saint Christopher P. Removal of emerging drugs of addiction by wastewater treatment and water recycling processes and impacts on effluent-associated environmental risk. Sci Total Environ. 2019 Aug 25:680:13-22. DOI: 10.1016/j.scitotenv.2019.05.068.

25. Rosi-Marshall EJ, Snow D, Bartelt-Hunt SL, Paspalof A, Tank JL. A review of ecological effects and environmental fate of illicit drugs in aquatic ecosystems. J Hazard Mater. 2015 Jan 23:282:18-25. DOI: 10.1016/j.jhazmat.2014.06.062.

26. Fontes Mayana Karoline, Maranho Luciane Alves, Seabra Pereira Camilo Dias. Review on the occurrence and biological effects of illicit drugs in aquatic ecosystems. Environ Sci Pollut Res Int. 2020 Sep;27(25):30998-31034. DOI: 10.1007/s11356-020-08375-2.

27. Xingxing Yin, Changsheng Guo, Yanghui Deng, Xiaowei Jin, Yanguo Teng, Jian Xu, Fengchang Wu. Tissue-specific accumulation, elimination, and toxicokinetics of illicit drugs in adult zebrafish (Danio rerio). Sci Total Environ. 2021 Oct 20:792:148153. DOI: 10.1016/j.scitotenv.2021.148153.

28. Parolini Marco, Magni Stefano, Castiglioni Sara, Zuccato Ettore, Binelli Andrea. Realistic mixture of illicit drugs impaired the oxidative status of the zebra mussel (Dreissena polymorpha). Chemosphere. 2015 Jun:128:96-102. DOI: 10.1016/j.chemosphere.2014.12.092.

29. Sancho Santos Maria Eugenia, Grabicová Kateřina, Steinbach Christoph, Schmidt-Posthaus Heike, Šálková Eva, Kolářová Jitka, Staňová Andrea Vojs, Grabic Roman, Randák Tomáš. Environmental concentration of methamphetamine induces pathological changes in brown trout (Salmo trutta fario). Chemosphere. 2020 Sep:254:126882. DOI: 10.1016/j.chemosphere.2020.126882.

30. Horký Pavel, Grabic Roman, Grabicová Kateřina, Brooks Bryan W, Douda Karel, Slavík Ondřej, Hubená Pavla, Sancho Santos Eugenia M, Randák Tomáš. Methamphetamine pollution elicits addiction in wild fish. J Exp Biol. 2021 Jul 1;224(13):jeb242145. DOI: 10.1242/jeb.242145.

31. Bijlsma Lubertus, Emke Erik, Hernández Félix, Voogt Pim de. Investigation of drugs of abuse and relevant metabolites in Dutch sewage water by liquid chromatography coupled to high resolution mass spectrometry. Chemosphere. 2012 Nov;89(11):1399-406. DOI: 10.1016/j.chemosphere.2012.05.110.

32. Terzic Senka, Ahel Marijan. Illicit drugs in wastewater of the city of Zagreb (Croatia)-estimation of drug abuse in a transition country. Environ Pollut. 2010 Aug;158(8):2686-93. DOI: 10.1016/j.envpol.2010.04.020

33. United States Department of Justice, Office of the Inspector General, Audit Division, The Drug Enforcement Administration’s Clandestine Drug Laboratory Cleanup Program, Audit Report 10-29 (Washington: Office of the Inspector General, 2010). URL: https://www.oversight.gov/sites/default/files/oigreports/a1029.pdf.

34. Pal Raktim, Megharaj Mallavarapu, Kirkbride K Paul, Naidu Ravi. Illicit drugs and the environment - a review. Sci Total Environ. 2013 Oct 1:463-464:1079-92. DOI: 10.1016/j.scitotenv.2012.05.086.

Стаття надійшла до редакції 25.06.2024 р.

Received June, 25, 2024