Analysis of international approaches to regulation of pesticides in processed agricultural products (literature review)

  • Authors: L.P. Ivanova, T.V. Adamchuk, A.P. Hrynko, O.P. Kravchuk, H.I. Petrashenko
  • UDC: 547.6:613.2
  • DOI: 10.33273/2663-9726-2021-55-2-94-99
Download attachments:

L.I. Medved's Research Сenter of Preventive Toxicology, Food and Chemical Safety, Ministry of Health, Ukraine (State Enterprise), Kyiv, Ukraine


ABSTRACT. Object . Analysis of pesticide regulations documents and scientific works regarding processed agricultural products.

Results. The principles to establish maximum residue levels (MRLs) for active ingredients of pesticides in raw agricultural commodities (RACs) and processed products are currently available in the European Union and Ukraine and are provided by the WHO Commission “Codex Alimentarius” and the Joint FAO/WHO Meeting on Pesticide Residues (JMPR) were reviewed.

The European Food Safety Authority (EFSA) project with the overall objective is to develop a database of validated processing factors based on the residue definitions for enforcement, which is compatible with the EFSA food classification and description system was outlined.

The European Association of Plant Producers of the EU Vegetable Oil and Proteinmeal Industry (FEDIOL) position on pesticide MRLs in vegetable oils and fats were described. This concept has identified two main elements allowing to give an indication of the fat solubility of an substances. In particular, variants of interpretation of the octanol/water partition coefficient (log Pow) were analyzed. It can be used to predict whether the substance is fat - or water-soluble and to provides an estimate of the tendency of a active ingredients of pesticides to bioaccumulate in fat. In the case of vegetable oils, MRLs can be approximated based on the physico/chemical properties of the pesticides and on the oil content of the raw agricultural commodities (theoretical processing factors from oilseeds seed to oil).

Conclusions. The review determines the necessity of improve Ukrainian pesticides regulation procedure and the development of a risk-oriented approach to the selection of priority indicators for the set of MRLs of pesticides in agricultural processed products.

Key Words: pesticides, residues, processed products, oilseeds.



1. Проданчук МГ. Токсиколого-гігієнічні основи безпечності харчових продуктів. Журнал АМН України. 2002; 8(4): 693-702.

2. Yigit Nuran, Yakup Sedat Velioglu. Effects of processing and storage on pesticide residues in foods. Critical Reviews in Food Science and Nutrition. 2020; 60(21): 3622-41.

3. Комиссия «Кодекс Алиментариус»: руководство по процедуре. 26-е изд. Рим: ФАО/ВОЗ; 2018; 279 с.

4. Regulation (Ec) No 396/2005 of the European parliament and of the Council of 23 February 2005 on maximum residue levels of pesticides in or on food and feed of plant and animal origin and amending Council Directive 91/414/EEC. Official Journal of the European Union. 2005; 48: 1-17; [Electronic resource]. URL:

5. Scholz R, Herrmann M, Kittelmann A, Schledorn M, Donkersgoed G, Graven C et al. Compendium of Representative Processing Techniques investigated in regulatory studies for pesticides. EFSA supporting publication. 2018; [Electronic resource]. URL:

6. Donkersgoed G, Boogaard C, Graven C, Koopman N, Mahieu K, Velde-Koerts T et al. Database of processing techniques and processing factors compatible with the EFSA food classification and description system FoodEx2 related to pesticide residues, Objective 2: Linking the processing techniques investigated in regulatory studies with the EFSA food classification and description system FoodEx2. EFSA supporting publication. 2018; 25 p; [Electronic resource]. URL: https://doi:10.2903/sp.efsa.2018.EN-1509.

7. Scholz R, Donkersgoed G, Herrmann M, Kittelmann A, Schledorn M, Graven C. European database of processing factors for pesticides. EFSA supporting publication 2018; 50 р; [Electronic resource]. URL: https://doi:10.2903/sp.efsa.2018.EN-1510.

8. FEDIOL position on pesticide Maximum Residue Levels (MRLs) in vegetable oils and fats. 2018. Ref. 11SAF181_rev1 [Electronic resource]. URL:

9. FAO (Food and Agriculture Organization of the United Nations), 2005. Report of the Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group on Pesticide Residues Geneva, Switzerland, 20–29 Sept. 2005. [Electronic resource]. URL: .

10. EU Pesticides database Maximum Residue Levels [Electronic resource]. URL:

11. Допустимі дози, концентрації, кількості та рівні вмісту пестицидів у сільськогосподарській сировині, харчових продуктах, повітрі робочої зони, атмосферному повітрі, воді водойм, грунті: ДСанПіН 000 2001. затв. МОЗ України 20.09.01 №137. Київ; 2001; 244 с.

12. Гігієнічні нормативи і регламенти безпечного застосування пестицидів та агрохімікатів, затверджені наказом МОЗ України 02 лютого 2016 року № 55 (у редакції наказу Міністерства охорони здоров'я України від 28 травня 2020 року № 1276), зареєстрованим у Міністерстві юстиції України 23.06.20 р. за №567/34850. [Електронний ресурс]. Режим доступу:


Стаття надійшла до редакції 15.06.2021 р.