L.I. Medved’s Research Center of Preventive Toxicology, Food and Chemical Safety, Ministry of Health, Ukraine (State Enterprise), Kyiv, Ukraine

SUMMARY. Aim. Review of guidelines of the European Union (EU) and the Organization for Economic Cooperation and Development (OECD) on pre-registration methods for analyzing pesticide residues and assessing the risk of pesticide exposure to environment state and its impact on human and animal health, and provide proposals for the development of domestic documents in this area.

Materials and Methods. Analytical review of EU and OECD governing and legislative documents and scientific publications on the development and use of pesticide analysis methods for pre-registration control of residues and pesticide risk assessment for humans, animals and the environment. Ukrainian legislative documents regulating the development and use of methods for analyzing pesticide residues for pre-registration control require significant revision in accordance with the requirements of the EU and OECD.

Results and Conclusions. A proposal is formulated on the need to create a domestic guide for the development and use of pre-registration methods for analyzing pesticide residues and assessing the risk of pesticide exposure to environment state and its impact on human and animal health on the basis of guiding documents of the European Union (EU) and the Organization for Economic Cooperation and Development (OECD).

Keywords: plant protection products (PPP), pesticides, maximum residue limits (MRL), methods for analyzing pesticide residues, pre-registration methods for analyzing pesticide residues, pesticide risk assessment.

СПИСОК ВИКОРИСТАНИХ ДЖЕРЕЛ / REFERENCES

1. ОECD Guidance Document on Crop Field Trials. Second Edition. Series on Pesticides No.66 Series on Testing & Assessment.No.164.2016:42. ttps://doi.org/10.1787/2794fdd6-en

2. Economy Division, Food and Agricultural Organisation of the United Nations. Principles and Methods for the Risk Assessment of Chemicals in Food. WHO &FAO.2008.Update 2020:689.URI https://wedocs.unep.org/20.500//822/29558 ISBN 978 92 4 1572 40 83.

3. OECD Guidance Document on Overview of Residue Chemistry Studies (As Revised in 2009). Series on Testing and Assessment Number 64 and Series on Pesticides Number 32.2009:93 https://one.oecd.org>MONO(2009) 31>pdf

4. Regulation (EC) No 1107/2009 of the European Parliament and of the Council of 21 October 2009 concerning the placing of plant protection products on the market and repealing Council Directives 79/117/EEC and 91/414/EEC. OJ L 309, 2009: 1–50. ELI: http://data.europa.eu/eli/reg/2009/1107/oj

5. SANTE/2020/12830 (combined guidance). Guidance Document on Pesticide Analytical Methods for Risk Assessment and Post-approval Control and Monitoring Purposes. Supersedes Guidance Documents SANCO/3029/99 and SANCO/825/00. 50 р. https://food.ec.europa.eu/

6. Organisation for Economic Co-operation and Development. Series on Pesticides. Number 39. Guidance Document on Pesticide Residue Analytical Methods. OECD,Paris 2007: 34. https://one.oecd.org›MONO(2007)17.pdf

7. European Commission. Directorate General Health and Consumer Protection. SANCO/3030/99 rev.5 Technical Active Substance and Plant protection products: Guidance for generating and reporting methods of analysis in support of pre- and post-registration data requirements for Annex (Section 4) of Regulation (EU) No 283/2013 and Annex (Section 5) of Regulation (EU) No 284/2013.2019:21. https://food.ec.europa.eu/

8. Cоmmisssion Regulation (EU) No 283/2013 of 1 March 2013 setting out the data requirements for active substances, in accordance with Regulation (EC) No 1107/2009 of the European Parliament and of the Council concerning the placing of plant protection products on the market. OJ.L93,2013:84. doi:10.3000/19770677.L_2013.093.eng

9. Cоmmisssion Regulation (EU) No 284/2013 of 1 March 2013 setting out the data requirements for plant protection products, in accordance with Regulation (EC) No 1107/2009 of the European Parliament and of the Council concerning the placing of plant protection products on the market. OJ.L93 2013:85-152 https://www.fao.org › details

10. Guidance SANTE 11312/2021 – Analytical quality control and method validation procedures for pesticide residues analysis in food and feed European Commission 2022:57 https://food.ec.europa.eu/

11. Commission Directive 2002/63/EC of 11 July 2002 establishing Community methods of sampling for the official control of pesticide residues in and on products of plant and animal origin and repealing Directive 79/700/EEC (Text with EEA relevance) OJ L 187, 2002: 30–43 ELI: http://data.europa.eu/eli/dir/2002/63/oj

12. Commission Regulation (EU) No. 691/2013 amending Regulation (EC) No. 152/2009 as regards methods of sampling and analysis. OJ, L196.2013:1-12. http://faolex.fao.org/docs/pdf/eur125961.pdf

Стаття надійшла до редакції 19.06.2025 р.

Received June, 19, 2025